Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a promising drug target in the treatment of age-related diseases, such as neurodegenerative diseases and cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4R)-1-(tert-butoxycarbonyl)-4-hydroxyprolyl-N-benzyl-N6-ethanethioyl-L-lysinamide | 0.05 mM, 83.4% inhibition | Homo sapiens | |
(4R)-1-(tert-butoxycarbonyl)-N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-4-hydroxyprolinamide | 0.05 mM, 97.1% inhibition | Homo sapiens | |
(4R)-4-hydroxyprolyl-N-benzyl-N6-ethanethioyl-L-lysinamide | 0.05 mM, 89.3% inhibition | Homo sapiens | |
(4R)-N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-4-hydroxyprolinamide | 0.05 mM, 96.8% inhibition | Homo sapiens | |
1-(tert-butoxycarbonyl)prolyl-N-benzyl-N6-ethanethioyl-L-lysinamide | 0.05 mM, 93.7% inhibition | Homo sapiens | |
methyl N2-(tert-butoxycarbonyl)-N6-ethanethioyl-L-lysyl-D-alaninate | 0.05 mM, 81.3% inhibition | Homo sapiens | |
N-[(2S)-6-(ethanethioylamino)-1-oxo-1-[(2-oxo-2-phenylethyl)amino]hexan-2-yl]-5-oxoprolinamide | 0.05 mM, 98.2% inhibition | Homo sapiens | |
N-[(2S)-6-(ethanethioylamino)-1-[[2-(morpholin-4-yl)ethyl]amino]-1-oxohexan-2-yl]-6-oxoheptanamide | 0.05 mM, 61.1% inhibition | Homo sapiens | |
N2-(tert-butoxycarbonyl)-N6-ethanethioyl-N-[2-(4-methoxyphenyl)-2-oxoethyl]-L-lysinamide | 0.05 mM, 95.6% inhibition | Homo sapiens | |
N2-(tert-butoxycarbonyl)-N6-ethanethioyl-N-[2-(morpholin-4-yl)ethyl]-L-lysinamide | 0.05 mM, 37.5% inhibition | Homo sapiens | |
N2-[(benzyloxy)carbonyl]-N6-ethanethioyl-N-[2-(morpholin-4-yl)ethyl]-L-lysinamide | 0.05 mM, 54.9% inhibition | Homo sapiens | |
N6-ethanethioyl-N2-(6-oxoheptanoyl)-N-(2-oxo-2-phenylethyl)-L-lysinamide | 0.05 mM, 97.7% inhibition | Homo sapiens | |
prolyl-N-benzyl-N6-ethanethioyl-L-lysinamide | 0.05 mM, 94.8% inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96EB6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine | Fluor de Lys is a fluorogenic, acetylated peptide substrate for human sirtuin 1, based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases | Homo sapiens | nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT1 | - |
Homo sapiens |
sirtuin 1 | - |
Homo sapiens |